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In June 2021, the FDA approved its use for chronic weight management in adults who are overweight or obese A 2022 study finding once patients go off the medication the average weight gain rebound is about 2/3 of the total weight lost

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It was initially shown that in drug addicts, who were accidentally exposed to MPTP, there was a depletion of pigmented nerve cells in the substantia nigra, accompanied by astrogliosis and clustering of microgliosis around nerve cells [41], thus presenting some PD-like features

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doi: 10.1073/pnas.042707999 75 EmanueleS.CelesiaA.DAnneoA.LauricellaM.CarlisiD.De BlasioA.et al