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This innovative analysis highlights the spatiotemporal specificity of various SIRT1 activators, emphasizing that tissue-selective delivery and dynamic dosage optimization are crucial for overcoming clinical translation challenges

Notably, while simultaneous substitution of these residues negatively impacts ternary complex formation and ubiquitylation of BRD4 BD1 (Extended Data Fig

Both compounds require refrigeration for optimal stability, both are damaged by freezing, and both tolerate brief room temperature excursions

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