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Mice were placed onto a cage hopper and infused with semaglutide, GLP-1MK-801 or vehicle (isotonic saline) over 60 s at a total infusion volume of 2 l through a Hamilton syringe mounted onto an automated syringe pump (Harvard Apparatus) and a 33-gauge internal cannula (PlasticsOne, C315IS-4/SPC, 2.5 mm)

These medications extend the signal, helping maintain satiety, regulate insulin secretion, and stabilize blood sugar levels

Research Dosing Protocols and Timing Establishing dosing protocols requires balancing effectiveness against side effects while accounting for the different pharmacokinetics of each compound

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