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Taste changes

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These include: Nausea (very common, affecting more than 1 in 10 people) Diarrhoea, constipation, or vomiting Abdominal pain or bloating Reduced appetite (this is part of the therapeutic effect) These symptoms typically improve over time as your body adjusts to the medication

Nausea diminishes or disappears entirely

While these trials were not specifically designed to assess joint pain, patients with obesity-related joint pain who achieve significant weight loss through GLP-1 therapy often report improved mobility, reduced need for analgesics, and enhanced ability to engage in physical activitycreating a positive cycle of further weight management and joint health

The key is preventing appetite suppression from causing chronically low protein or calorie intake, which would undermine muscle recovery