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Some people use them together, others use one or the other
Ridha Z et al, Aesthetic Surgery Journal 44(11):NP809-NP818, PMID 38874170) describes GLP-1 receptors on adipose-derived stem cells (ADSCs) and fibroblasts in skin, and proposes that activation of these receptors may reduce protective cytokine production from ADSCs, increase oxidative stress on neighboring fibroblasts, reduce ATP production through altered glucose uptake, and indirectly reduce local estrogen production from dermal white adipose tissue
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Glucagon receptor activation has mixed cardiovascular effects, including some vasodilatory effects through cAMP signaling, balanced against the small heart rate increase The BP effects of retatrutide may include a small contribution from these direct mechanisms on top of the larger weight-loss-mediated effect
Even at moderate doses , retatrutide outperformed existing incretin mimetics, with 8 mg weekly doses yielding reductions exceeding 20%
