Clinical trials such as the STEP programme (semaglutide) and SUSTAIN studies show that: Initial weeks : Modest weight loss primarily from reduced caloric intake Months 23 : More noticeable reduction becomes evident Months 36 : Continued steady weight loss as dose escalates Months 612 : Peak weight loss approaches, with most studies showing maximal effect by 1218 months It is important to recognise that GLP-1 medications require dose titration starting at a low dose and gradually increasing over several weeks according to the specific product's SmPC
Statins: absorption may be affected
Poor sleep can increase cortisol levels and exacerbate inflammation, while quality deep sleep has been shown to reduce anxiety levels after just one night
Our clinician team can help determine if these treatments are right for your diabetes management plan
Per Trimi's published Refund Policy (last updated June 17, 2026): you need to stay on a continuous paid plan for six full months, take the medication as directed, log both a starting weight and a 6-month weight in the patient portal, and complete provider check-ins
New England Journal of Medicine , 387(24), 2245-2257