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High total IgG to N/C-terminus/SmTSP-2 chimera and Sm29+rSm-TSP-2 along with high production of IFN- and TNF- -indicative of a Th1-biased profile - were detected following cercarial challenge

Ongoing studies continue to examine cellular communication, angiogenic signaling, cell migration, cytoskeletal organization, extracellular matrix remodeling, and tissue homeostasis

The reported cellular readout is synaptogenesis increased dendritic-spine density in hippocampal neurons

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