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Briefly, wild-type (wt, 5-GAGTGTGGATGACCCTTGGT-3) or mutant (mut, 5-CTCACACCTACTGGGAACCA-3) sequence in MBOAT1 promoter region or wt (5-GGTAAAGAGGCGCGGGGA-3) or mut (5-CCATTTCTCCGCGCCCCT-3) sequence in METTL1 promoter region was fused into luciferase pGL3-basic reporter vector (Promega, Madison, USA) to construct pmirGLO-MBOAT1-wt/-mut or pmirGLO- METTL1 -wt/-mut (sequences in Supplementary Table S6)

The modest reduction in overall MA-PD enrollment between 2025 and 2026 (from 31.6 million to 31.4 million) reflects a shift in enrollment among employer group plan enrollees from group MA-PD plans to group MA-only plans with separate PDPs

Timing: Best taken in the morning on an empty stomach or before training to support antioxidant levels during exercise

Kretzschmar, M

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