So but I understand, though, that one of the problems with the GLP-1s that you were using early in your research, though, was that it actually didn't last long in the human body when infused
Results confirmed liraglutide's superiority: HbA1c reduction: -1.48% (liraglutide) vs -1.28% (exenatide ER) Weight loss: -3.57 kg (liraglutide) vs -2.68 kg (exenatide ER) Weight Loss Comparison# Exenatide (DURATION Program)# Exenatide was developed for type 2 diabetes, not weight management: DURATION-1: 3.7 kg weight loss with Bydureon over 30 weeks DURATION-5: 2.3 kg weight loss over 24 weeks Three-year extension: 2.3 kg sustained weight reduction No FDA approval for chronic weight management Liraglutide (SCALE Program)# Liraglutide was specifically developed for obesity at the higher 3.0 mg dose: SCALE Obesity and Prediabetes (Pi-Sunyer et al., NEJM 2015): 8.0% mean weight loss at 56 weeks 63.2% achieved 5% or more weight loss
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Your repair capacity goes down as you grow older because your mitochondrial energy production is going down
