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Notably, under BSO treatment, these molecules may increase cysteine availability but should not restore GSH levels, as BSO irreversibly inhibits -glutamylcysteine synthetase (-GCS) the enzyme responsible for GSH synthesis downstream of cysteine 48

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Microplate-compatible formats allow rapid data acquisition, and many probes are compatible with automated liquid handling systems used in academic and contract research laboratories

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This also affects the stroma, in reducing both angiogenesis as well as possibilities of immune escape by tumour cells