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Inclusion criteria for the patients in this study included age between 18 and 65 years and a diagnosis of primary polydipsia based on polydipsia of greater than 3000 mL per day and polyuria of greater than 50 mL/kg body weight per day

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Previous studies showed that it did not significantly suppress the growth of KRAS-derived PDAC cells in vitro or in vivo because these cells mounted an adaptive metabolomic response, suggesting the importance of combined therapy for avoiding metabolic adaptation in response to GLS inhibition 45

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