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That is a problem for several reasons: GLP-1 medications carry boxed warnings about thyroid C-cell tumors in rodents and are contraindicated in people with a personal or family history of medullary thyroid carcinoma or MEN2

What are GLP-1s: GLP-1, or glucagon-like peptide-1, is a hormone that plays a role in appetite regulation and blood sugar management

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Insulin degludec is associated with lower rates of overall, symptomatic, nocturnal, and severe hypoglycemia compared to glargine U-100 [78,80,111-113]

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