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As with all medications, these results reflect trial conditions, and the full safety profile will become clearer once the drug is used in larger, more diverse populations

Comparative efficacy of THR- agonists, FGF-21 analogues, GLP-1R agonists, GLP-1-based polyagonists, and Pan-PPAR agonists for MASLD: a systematic review and network meta-analysis

The results may be reconcilable by the existence of distinct Gipr -expressing target cell populations with different physiological roles and responsiveness

10.1016/j.clinthera.2020.05.017 Clin

Indeed, the permeability of the intestinal mucosa is considered a crucial factor in innate defense, and disruption of barrier function can lead to excessive activation of immune cells (127)

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