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This symptom may arise through several mechanisms, including low blood glucose (hypoglycaemia), dehydration from gastrointestinal effects, orthostatic hypotension, or reduced caloric intake

Examples of possible drug interactions of semaglutide include: If you are taking these medications, consult your healthcare provider before starting semaglutide to avoid possible drug interactions

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In litigation filed in early 2026, a major GLP-1 manufacturer alleged that testing of compounded injectable semaglutide products found impurity levels as high as 86%, with compounded oral formulations containing impurities as high as 75%