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Good performance requires proper design and proper material selection

10.1210/endo.133.6.8243312 Endocrinology 38 VejrazkovaD.LischkovaO.VankovaM.StanickaS.VrbikovaJ.LukasovaP.et al (2017)

They are giving it a (literal) shot with microdosing, often with minimal medical supervision

These medications should only be used when clinically indicated and under the guidance of a qualified healthcare professional

But the FDA has restricted the mass compounding of GLP-1s for safety and regulatory concerns

To integrate evidence across datasets, we performed a meta-analysis combining MR estimates from all cohorts, which allowed us to strengthen statistical power, assess effect consistency, and ensure the robustness of the observed associations across diverse populations