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El ensayo OASIS 1, en personas con obesidad y sobrepeso sin DM2, evidenci que la SEMA oral a 50 mg logr una prdida media del 15,1% del peso corporal frente al 2,4% con placebo en 68 semanas, aunque con una incidencia relevante de efectos gastrointestinales y disestesias en el 13% de participantes, lo que ha impulsado el estudio de dosis intermedias para optimizar eficacia y tolerabilidad

Curr Neurol Neurosci Rep 25 , 36 (2025)

Is the claimed use authorised in the UK

Always keep the prefilled syringes in the original carton to protect from light

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Fatty acid side chain: A C-18 diacid chain is attached to the C-terminus, extending the half-life to approximately 7 days and enabling once-weekly dosing