The authors concluded it appears effective and generally safe
Furthermore, a recent population-based, case-control study of more than 40 000 US pregnancies showed that the concurrent high consumption of vitamin B 6 , vitamin B 12 , choline, betaine and methionine in addition to folic acid was associated with a higher NTD reduction compared with the increased intake of a single nutrient (Reference Petersen, Smith-Webb and Shaw84)
PMID: 143 GreffDJuhszAEVancsaSVaradiASiposZSzinteJet al
Across those studies, doses vary quite a bit often ranging from 600mg to 1,800mg per day, depending on the condition being studied.1 10 20 22 That range is one reason we like 600mg capsules for most people
This increases local pressure and makes the injection feel more intense
There are different tests