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28 Over and above, it is known that there is abundant expression of DMT1 in the proximal tubule and collecting ducts of the kidney

While the risk of severe hypoglycemia is low when used as monotherapy, the risk may increase when combined with other diabetes medications that can cause hypoglycemia

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Early signals of complexity, pleiotropy, or tolerability frequently discouraged further development, despite the possibility that these features could be harnessed through modern pharmacologic strategies