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Construction and evaluation of brain-specific Insr-knockout mice (C57BL/6J-Insr em1cyagen ) Brain-specific Insr-knockout mice were generated by using Cre-loxP system 59

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The fusion of a co-agonist or a single gut hormone with either the light or heavy chain of the antibody palivizumab provides mixed agonists capable of potently activating two or more receptors simultaneously in a balanced manner [93]

Of particular interest is that NK-lysin fragments and derivates also show potent antimicrobial activities by concurrent optimization of peptide stability and minimized cytotoxicity