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Weight loss after gastric bypass surgery in women is followed by a metabolically favorable decrease in 11 beta-hydroxysteroid dehydrogenase 1 expression in subcutaneous adipose tissue

However, indirect factors such as dehydration from gastrointestinal side effects and rapid weight loss may theoretically increase stone risk

This is one of the key drivers of mitochondrial failure, accumulation of irreparable DNA damage and cellular aging across tissues

The timeline for potential approval depends on the results of ongoing Phase 3 trials, which will provide more comprehensive data on both efficacy and long-term safety

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contributed to clinical study data analysis, critical manuscript revision and final manuscript approval