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(From SGLT2 inhibition in the diabetic kidney from mechanisms to clinical outcome) These effects translate into meaningful reductions in morbidity and mortality from diabetes-related renal and cardiovascular disease, as shown in the EMPA-REG trial and large meta-analyses

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Meanwhile, Eli Lilly, manufacturer of competing GLP-1s Mounjaro and Zepbound, is continuing to do pretty well

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Contrary to the physiological functions, GGT and G-SH (especially in the presence of pro-oxidants such as iron and copper) can also become potentially harmful through possible pro-oxidant and carcinogenic effects occurring via free radical formation, peroxidation of lipids, and, eventually, mutagenesis [19]