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When Wnt signaling declines with age, regeneration slows
2.1 Mechanistic evidence of natural compounds Preclinical studies have demonstrated that these natural products modulate multiple AD-related pathways including reducing A burden, inhibiting tau hyperphosphorylation, preserving mitochondrial function, and suppressing pro-inflammatory cytokines (Wang et al., 2022b)
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Bone morphogenetic protein (Bmp) signaling in development and human diseases
The cytoprotective properties of Sp extended to decreased progression of degenerative phenotypes in Drosophila Parkinson model due to retention of redox balance in dopaminergic neurons and maintenance of their architecture
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