The increase in appetite might be related to the agonistic effect of Ipamorelin on ghrelin receptors which may stimulate hunger, as well as the increase in insulin production observed in animal experiments
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However, GLP-1 drugs carry known risks and, since their use for weight loss is recent, may carry unforeseen risks as well
This is roughly equivalent to the maximum maintenance dose for diabetes management with Ozempic (2 mg weekly) but still below the maximum weight loss dose of Wegovy (2.4 mg weekly)
[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Baci D., Bruno A., Cascini C., Gallazzi M., Mortara L., Sessa F., Pelosi G., Albini A., Noonan D.M