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GLP-1 is secreted from L cells in the small intestine upon food stimuli including carbohydrates, lipids, proteins, amino acids, bile acids and short-chain fatty acids

Mechanism of Action: Why Weekly Dosing Works So Effectively Semaglutide works by mimicking glucagon-like peptide-1 (GLP-1), a naturally occurring hormone that regulates appetite and blood sugar control

Understanding the typical timeline helps you prepare, persist through temporary discomfort, and recognize when something requires medical attention versus normal adaptation

Therefore, the reduction of foam cells with GLP-1RAs treatment is speculated to inhibit vascular senescence and delay the progression of atherosclerosis

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It increases our basal metabolic rate (how much energy we burn at rest), meaning we burn more energy throughout the day, and it promotes the breakdown of stored fat for fuel