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The participants were given different doses of bupropion in combination with a calorie-restricted diet and regular exercise for 24 weeks

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The mitochondrial pellets (100200 g) were similarly extracted either in 0.6 M perchloric acid or 0.25 M potassium hydroxide in 50% ethanol and were diluted to 1:10 times for NAD + and 1:5 times for NADH in 100 mM sodium phosphate buffer

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