( 10.1016/S0140-6736(1460976-4) [DOI] [PubMed] [Google Scholar] 104.Ahmann AJ, Capehorn M, Charpentier G, Dotta F, Henkel E, Lingvay I, Holst AG, Annett MP, Aroda VR
The former are nitrile-containing inhibitors that act on the DPP4 substrate involving production of a reversible covalent enzymeinhibitor complex, which gradually and slowly dissociates from the substrate leading to a lasting inhibitory activity, even after the drug has been inactivated
GLP-1RAs (GLP-1 receptor agonists) are a class of drugs that mimic the action of the GLP-1 hormone and work by stimulating the production of insulin, slowing down food digestion and inducing satiety signals in the body
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
A perceived loss of effectiveness usually indicates a plateau rather than true medication failure
Georges University School of Medicine, her medical school
