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The Y402H mutation may prevent the binding of CFH to its regulator molecule, heparan sulfate

[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Knezevic M., Gojkovic S., Krezic I., Zizek H., Malekinusic D., Vrdoljak B., Vranes H., Knezevic T., Barisic I., Horvat Pavlov K., et al

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Allergy 35 , 10961103 (2005)

Insert the needle at a 45 to 90 degree angle depending on needle length and tissue thickness

For this reason, the inability to convert 5-methyl-THF to THF (as occurs via the B12- and folate-dependent enzyme, methionine synthase (also known as homocysteine methyltransferase) and then to any other THF derivative leads to trapping of folate in the reduced form