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Accessed 10/6/2025, Barsan ME

Results: Injection of FOXO4-DRI in both naturally aged and induced aging mice effectively suppressed aortic aging and improved aortic function

Heitzer T, Schlinzig T, Krohn K, Meinertz T, Munzel T

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Concurrently, GHK-Cu downregulates pro-inflammatory cytokines (IL-6, TNF-alpha), pro-fibrotic mediators, and several metalloproteinases involved in excessive tissue degradation

The molecule has a very high affinity for copper (II) and forms the chelate GHK-Cu