But this only occurred when they had their usual gut bacteria: mice who were fed antibiotics to kill this bacteria experienced no such effect
In terms of kidney function, while the initial eGFR for GLP-1 RAs users was notably lower, the difference was no longer significant by the D60-90 interval, hinting at a possible stabilization or amelioration in kidney function attributed to GLP-1 RAs therapy (Figure S2)
Clinical Nutrition ESPEN, 60, 109115
Patients on maintenance doses retained 70 to 85% of their peak weight loss at two years, compared to 40 to 60% retention for those who stopped completely but implemented lifestyle changes, and less than 30% for those who stopped without significant lifestyle modification
Individual results vary based on factors including starting weight, adherence to the program, dietary habits, and physical activity level
Breaking this cycle by prioritizing sleep hygiene, consistent bedtimes, cool bedroom temperature, limiting screens before bed, often produces surprisingly broad improvements across multiple symptom categories