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It is a analog of human IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arginine (Arg or R) for the Glutamic Acid (Glu or E) at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus

Ge SL, Zhu TC, Li Y (2012) Expression of bacterial GshF in Pichia pastoris for glutathione production

The cardiovascular benefits demonstrated in long-term trials are particularly relevant for patients with type 2 diabetes or established heart disease

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other sleep-support approaches Understanding where DSIP sits relative to other options can help patients and clinicians make more informed decisions: Melatonin primarily helps with sleep onset and circadian alignment

J Immunol 138 , 32133218 (1987)