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Clark E, Plint AC, Correll R, Gaboury I, Passi B (2007)

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TB-500 is synthetic thymosin beta 4, a 43-residue N-terminally acetylated polypeptide of 4963.4 g/mol and the principal G-actin sequestering molecule in eukaryotic cells

Conversely, activation of APC GABA neurons or the APC GABA -MD circuit induces freezing responses and relieves pain, mimicking fear-induced analgesia

Dysregulation in mitochondrial sheath formation can result in reduced sperm midpiece flexibility, impaired midpiece structural stability and perturbed energy production, all of which are detrimental for effective sperm motility and overall male fertility