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Although desnutrin/ATGL mRNA is downregulated in obese rats (130), adiponutrin mRNA is induced 50-fold (9)

Given the broad scope and varying definitions of rare diseases worldwide, our analysis focused on the top ten rare diseases with the highest levels of research and development (R&D) activity 14

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However, long-term safety data is limited, and its full risk profile is not yet completely understood

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