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Gastrointestinal adverse effects are the most commonly reported side effects of GLP-1 receptor agonists, occurring in a significant proportion of patients

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When taken together, these effects may be additive, potentially affecting treatment adherence and quality of life

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The changes were subtle at first, but by week three, they became visible

The expression of proteins filaggrin (FLG) and loricrin (LOR) was evaluated by immunofluorescence, while the expression of mRNAs FLG and LOR in the skin was measured via qRT-PCR