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GLP-1 was identified in the early 1980s, and its insulinotropic and anorectic properties were rapidly established
Even with insurance, many plans require prior authorization, step therapy through cheaper medications first, or simply do not cover weight loss indications at all
Prior to the widespread adoption of lipidation, albumin binding, and fusion strategies, many peptides were dismissed as clinically impractical solely because of their dosing frequency
The BALANCE Model is designed to test whether lower negotiated prices as applied to currently covered indications will lower program spending
2018 Dec;108:952-962
Global demand for semaglutide and liraglutide exceeds the present supply, which might be related to their off label uses and misuse [7]
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