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The observed reduction in glycerol may reflect increased utilization for gluconeogenesis and ketogenesis, or a decrease in lipolytic activity, metabolic pathways that could all impact the ability to sustain energy production during or between seizures 23

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Alterations in G6PD levels may promote tumor cell proliferation or apoptosis via the STAT3/5 pathway in a human melanoma xenograft model, and G6PD regulated STAT3 activity via the NADPH oxidase 4-NADPH-ROS-proto-oncogene tyrosine protein kinase/protein-tyrosine phosphatase 1D signaling pathway in A375 melanoma cells (69,70)

As people age, they produce less glutathione

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