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Patients prone to heart disease might fare best on medication that includes a GLP-1 component
[DOI] [PubMed] [Google Scholar] 10.Kushner R.F., Calanna S., Davies M., Dicker D., Garvey W.T., Goldman B., Lingvay I., Thomsen M., Wadden T.A., Wharton S., et al
Incretin antagonists While incretin agonists, such as GLP-1s, activate hormone receptors in the gut, other drugs known as antagonists take the approach of shutting down certain functions
The hypothalamus, particularly the arcuate nucleus, contains GLP-1 receptors that modulate hunger and satiety signals
In 2019, the FDA approves semaglutide (Rybelsus), the first oral GLP-1 analog treatment for adults with type 2 diabetes
144,145 It is worth considering the combined outcomes from the full effect of GLP-1RA on hepatic steatosis and metabolic syndromes such as T2DM and dyslipidemia
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