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it regulates the immune system, drives inflammation up or down, and communicates constantly with the brain through the gutbrain axis
Novel mechanisms involved in leptin sensitization in obesity
This means eating balanced meals that combine complex carbohydrates with protein and healthy fats, avoiding excessive refined sugar, and not skipping meals
For semaglutide (currently on 2.4 mg weekly): Weeks 1-2: Step down to 1.7 mg weekly
This pattern fits with the fact that central GLP-1 can inhibit feeding behaviours independently from GLP-1-gut-brain signalling 7
Acknowledgments This work was partially supported by NIH 5UG3DA047717 (H.M.M
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