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Csajbok et al., 2019

Placing your semaglutide in an easily accessible location within your carry-on bag prevents unnecessary delays at the checkpoint

10.1124/pr.118.015578 Pharmacol

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Therefore, we engineered a chimeric protein by fusing GLP-1 to an HSA-binding DARPin with a high affinity for albumin that takes advantage of the extended plasma circulation of HSA to develop a long-acting variant of GLP-1

It employs a Dual Activation and Dual Amplification strategy: Dual Activation: The system directly activates the GLP-1 pathway in L-cells and indirectly activates GLP-1 by optimizing the gut microbiome to produce SCFAs, which fuel GLP-1 production