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Small increases in those MSK codes are definitely not necessarily drug side effects: they could come from more clinic contact, detection bias, miscoding, activity-related aches during weight loss, or unmasking old pains as people move more

Aldosterone/renin ratio (ARR) is commonly used to screen for PA

The spots are usually flat, smooth, and painless

Benefits often increase over time with consistent use

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The STEP pediatric trial demonstrated that tirzepatide produced significant weight loss in adolescents ages 1217 compared to placebo, but long-term data in teenagers remains limited