How we reviewed this article: Current Version October 03, 2025 Written By John DiBella Fact-checked By Dr
Supports Red Blood Cell Production Vitamin B12 is crucial for the development of healthy blood cells
NNMT plays a role in regulating nicotinamide adenine dinucleotide (NAD+) metabolism, energy expenditure, and cellular signaling pathways
Many patients experience improved mood, energy, and mental clarity after treatment
As fat tissue grows and more NNMT is produced, higher amounts of hormones and pro-inflammatory signals are produced that are responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. NNMT is responsible for converting nicotinamide (NA) into 1-methylnicotinamide (1-MNA), which takes it out of the NAD salvage pathway (see the diagram below)
Unlike fat-soluble vitamins (A, D, E, and K) that can build up, B12 has a strong safety record and toxicity is rare