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It is due to a defective action of incretin hormones, mainly glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1)

Reconstitution: 2.0 mL bacteriostatic water per 10 mg vial gives 5 mg/mL for accurate unit measurements

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Thioredoxin-interacting protein (TXNIP) regulates Parkin/PINK1-mediated mitophagy in dopaminergic neurons under high-glucose conditions: implications for molecular links between Parkinsons disease and diabetes

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Thanks to its mechanism of action, by removing the injectable barrier, this formulation represents the first oral peptidic hormone-based therapy for the management of T2D