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In a phase 2 randomised controlled trial published in the New England Journal of Medicine (Jastreboff et al., 2023), participants receiving the highest doses of retatrutide achieved a mean weight reduction of approximately 1724% of body weight over 48 weeks, depending on dose

Weight loss may slow slightly from the pace of months 2 through 4, but total results are compounding

Take note that this combination should only be considered if the potential benefits are greater than the risks

For those without coverage, manufacturer discount programs can sometimes reduce costs

Here's how the drugs compare

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