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A study in Diabetes, Obesity and Metabolism found patients who discontinued GLP-1 therapy regained about two-thirds of their lost weight within one year

Kim, J., et al

"Some patients find that injecting in the evening helps reduce nausea," she says, noting that light carbohydrates like crackers can help settle the stomach

Long-term treatment with palmitate, a type of long-chain saturated fatty acid, can disrupt the rhythmic secretion of GLP-1 by suppressing the expression of the Bmal1 clock gene [141]