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Epitalon research specifically targets this population, with primate studies showing melatonin restoration only in aged subjects, not young ones
Abstract #51
For this reason, multiple surrogate matrices were investigated and 100 g/mL of bovine serum albumin (BSA) in water was found to be the best surrogate matrix
Restarting before this window closes means you're building on a suppressed baseline, which increases the dose required for equivalent effect and accelerates receptor desensitization over subsequent cycles