Figure 2: Diabetes and Incretin effect
Moreover, in addition to the direct action of GIP in adipose tissue to reduce serum triglyceride levels, GLP-1 may abolish the postprandial rise in triglyceride and free fatty acid concentrations by reducing intestinal absorption of dietary lipid, stemmed from the delayed gastric emptying (197, 198)
By tailoring each dose adjustment to the patient's specific progress and side effects, the guiding principle is to find the lowest effective dose that comfortably sustains long-term results, rather than rushing to the maximum dose in the shortest time possible
The baseline HbA1c in the tirzepatide arms was 8.18%8.19% and 8.15% in the study arm receiving dulaglutide
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Nooms own internal data also shows that the likelihood of experiencing side effects increases significantly as dosages increase