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In the cardiovascular domain, modulating bile acid signaling pathways is postulated to confer indirect cardioprotection by improving lipid metabolism and inhibiting inflammation, constituting an integral component of the microbiota-metabolism-epigenetics regulatory network 167

Individuals with cardiovascular disease or uncontrolled hypertension can experience potentially dangerous temporary increases in systolic and diastolic blood pressure when taking PT-141

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DEsposito V, Di Tolla MF, Lecce M, Cavalli F, Libutti M, Misso S, et al