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Exenatide restores GLP-1R expression and reduces mucin production in COPD airway cells by restoring FOXA2 function through activation of GLP-1R-peroxisome proliferator-activated receptor gamma (PPAR-)-phosphatase and tension homolog (PTEN) signaling, thereby increasing the ectopic and efficacy of other drugs in COPD and reducing the high morbidity and mortality induced by excess mucus

Therefore, if you take B12 supplements regularly, you should ensure that hydroxocobalamin is contained in addition to the active B12 forms

Taking metformin with food and gradually increasing doses can minimize these effects

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