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Deposition of -synuclein is started at first in the ANS, mostly in the dorsal motor nucleus of cranial nerves, and then spread to the other brain regions (Norcliffe-Kaufmann 2019)

Amidon GL, Lennerns H, Shah VP, Crison JR

Substantial weight loss may create a temporary discrepancy between the internal body self and the changed physical appearance, a phenomenon described in qualitative and psychodynamic work as ghost fat or identity lag [70, 71]

The details of each method are described below

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"A Phase 2 Randomized Trial of Survodutide in MASH and Fibrosis"