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1 Introduction Diabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus and is the leading cause of end-stage renal disease (ESRD) worldwide, accounting for approximately 40% of ESRD cases ( Histologically, DN is characterized by progressive glomerulosclerosis, tubulointerstitial fibrosis, and abnormal extracellular matrix deposition, resulting in irreversible nephron loss and functional decline (12)

[15] The MTHFR gene variation is associated with a buildup of homocysteine due to impaired methylation

Change Your Diet: Staying away from greasy and fatty foods may lessen your digestive side effects

doi: 10.1128/mBio.01418-16

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Systematic incidence rates from controlled human trials do not exist for this combination