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Vitamin B12 deficiency, in particular, is associated with peripheral neuropathy and altered skin sensation

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In the 72-week study of more than 1,600 overweight or obese adults with Type 2 diabetes, those who received the 36-milligram highest dose of orforglipron on average shed 10.5% of their weight, or about 23 pounds, versus 2.2% for those who received a placebo, achieving the main goal of the trial